Aims/Objectives

The DESTINATION Consortium aims to achieve the following throughout duration of the project:

• Development of an AI discovery platform

• Validation of an RNano scaffold for therapeutic delivery

• Creation of an intelligent library of lead cell-internalizing aptamers

• Animal models for proof-of-concept in vivo CAR-T, mRNA and CRISPR therapies

• Novel methods based on multicolor single molecule imaging tailored for RNA imaging

• DNA/RNA origami synthesis and conjugation to RNanos

• Logic gates (for mRNA protection)

• Optimised synthesis workflows

• Communication of outputs via international conferences, workshops and high-impact publications