Addressing this challenge requires a novel, biocompatible and scalable system capable of:
(1) protecting the mRNA from degradation in blood;
(2) evading the immune response;
(3) and providing high selectivity for targeted cells.
DESTINATION will generate an intelligent library of:
(a) programmable RNano scaffolds for attachment of packaged mRNA and
(b) RNA aptamers for laser-specific internalization of RNanos into cells.